Solubility and dissolution rate of Rosuvastatin calcium was studied in four media having different pH. The samples were analyzed by using UV Visible spectrophotometer. Rosuvastatin calcium shows more solubility in water and pH 6.8 phosphate buffer and lower and almost similar solubility in 0.1 N HCl and pH 4.5 Acetate buffer. Rosuvastatin calcium shows varying dissolution rate in all media and it was clearly observed that dissolution rate was increased as the drug passes through GIT. The solubility and dissolution data in various media is helpful in predicting the bioavailability and also in dissolution method development.
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